Minoxidil is known by many names crowd alopecia, hair loss is also welcomed by many. You know that minoxidil is used to treat hair loss in accordance with the principle of what is it? That is not all minoxidil good treatment for all hair loss has it? The use of minoxidil have side effects? Let clinical facts tell us.
The current study suggests that minoxidil can directly stimulate the hair follicle epithelial cell proliferation and differentiation; promote angiogenesis, increasing local blood flow; open potassium channels; make the conversion from the telogen follicles to the growth phase. Topical minoxidil minimal systemic absorption. There is sufficient clinical trials minoxidil for androgenetic alopecia, alopecia areata has a good effect, but require long-term medication to maintain efficacy. Hair Hair Extensions shorter the time, the smaller the area, the better the prognosis. High concentrations than the low concentration is effective, large-scale clinical trials have confirmed that topical minoxidil hair loss treatment is safe.
Minoxidil (minuodier) topical hair loss treatment mechanism.
Minoxidil is a vasodilator treatment of hypertension, but its mechanism of treating hair loss, is not primarily the expansion of blood vessels. According to experimental studies, in vitro follicle added minoxidil hair follicle growth time increase cultivation. Follicle hepatocyte growth factor and vascular endothelial growth factor are the two main growth factor dermal papilla of the hair growth cycle has an important regulatory role. Lachger other reports minoxidil hair papilla cells upregulates vascular endothelial growth factor mRNA expression. Minoxidil therefore considered by the above cytokines, growth and extension of maintaining follicle growth phase of hair follicles, the hair follicle so that miniaturization and increase the pro-angiogenic function of the dermal papilla, which plays an important role in the treatment of alopecia.
First, minoxidil topical treatment of male pattern hair loss
In 1988 the FDA approved a 2% solution of minoxidil topical treatment of male pattern androgenetic alopecia. After the 2294 cases of 18-50 year-old male patient with mild to moderate hair loss on top, 12 months of treatment, the number of groups minoxidil hair growth increases. Subsequently Trancik applications 5% minoxidil, and placebo-controlled in 393 cases of male pattern androgenetic alopecia, and after 48 months of treatment, the results of the application of 5% minoxidil group hair than 2% Minoxidil count 45% higher Seoul group, 5 times higher than in the placebo group. In 1997 the FDA approved 5% minoxidil solution can be used as the use of male pattern hair loss. Price et topical 5% minoxidil in promoting hair growth and increasing the effectiveness of hair were compared with placebo and no treatment group, the results are also said to Seoul Ming Minuo topical treatment to promote hair growth.
Second, the treatment of alopecia areata: Alopecia areata is a common chronic inflammatory skin disease, a significant proportion of patients have a tendency to heal, but relapse is common, longer duration or alopecia widely prognosis is poor. Many treatments can promote hair growth alopecia areata. Minoxidil treatment of alopecia areata have a certain effect, and showing a dose-dependent manner.
Third, minoxidil female androgenetic alopecia equally effective. A double-blind, placebo-controlled, multi-center trial to observe the efficacy of 2% minoxidil treatment of female androgenetic alopecia, 256 female patients treated 32 weeks with a precise objective evaluation of photographic technique of non-vellus hair regeneration number of treatment groups in assessing the regional average of 1 cm renewable non-vellus hair 23 in the placebo group was 11, observers believe that accepting a 2% minoxidil therapy, 13% had moderate hair regrowth, 50 % had mild hair regeneration, significantly higher than the placebo group, too, to accept a 2% minoxidil treatment, 60% reported new hair growth.
Fourth, androgen alopecia: 2% minoxidil solution treatment of male androgenetic alopecia, each 1 mL, 2 times a day for 3 months to 1/3 of the patients with mild to moderate hair growth, 12 months, 56% of patients have significantly improved appearance. A randomized, double-blind, placebo-controlled, multi-center clinical trial comparing 5%, 2% minoxidil and placebo therapy male androgenetic alopecia.
The results showed: 5% minoxidil hair growth promoting effect was better than 2% minoxidil and placebo were observed 5% minoxidil, 2% minoxidil and placebo on male androgenetic alopecia patient weight and quantity of hair, four groups of patients, nine patients in each group were treated with 5% minoxidil 2 percent minoxidil, placebo, and no treatment, double-blind study of the first three groups. Results: After 96 weeks treatment, hair, weight gain were 5% Minoxidil> 2% minoxidil> placebo were significant differences between the groups, but the increase in the number of hairs Human Hair Wigs was no significant difference in the proportion of stopping treatment and then observed for 24 Zhou, hair weight and number of minoxidil therapy to placebo levels dropped, indicating that minoxidil does not alter the genetic quality of androgenetic alopecia patients.
Adverse reactions: minoxidil solution main adverse reactions hirsutism. A large-scale safety trials showed that minoxidil androgenetic alopecia treatment is safe and effective, does not increase cardiovascular events, no significant systemic adverse reactions. Pelu-SO et al reported five cases of women with androgenetic alopecia 5% minoxidil treatment for 2 to 3 months after the occurrence of the face and limbs, severe hirsutism, but 1 to 3 months after treatment of facial and upper extremity hair disappear, 4 to 5 months of lower extremity hair disappear, hirsutism may absorb and hair follicles of these parts are highly sensitive about minoxidil and minoxidil system. U.S. FDA has approved 2% and 5% minoxidil solution for non-prescription drugs, the former applies to both men and women, the latter only applies to men. Minoxidil solution may cause irritation or allergic contact hypersensitivity, some patients may be symptoms of itching and scaling of the scalp, but for patients with allergic contact dermatitis patch test showed that the majority of patients and words, propylene glycol solvent is true allergens, rather than minoxidil itself lead. Therefore, to avoid replacing the solvent part of an allergic reaction. 5% minoxidil solution than 2% minoxidil topical solution more likely to cause irritation. The report said, using 5% topical minoxidil can cause contact dermatitis pigmentation.
